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مركز تحقيقات نوزادان، هفته جهاني شير مادر 10-16 مرداد ماه 96 شعار امسال تغذيه با شير مادر، كودك باهوش تر و قوي تر

خبرنامه 9


    مركز تحقيقات نوزادان>خبرنامه شماره 9

 
 
Effect of clofibrate in jaundiced term newborns
 
 
A. Mohammadzadeh, A.Sh. Farhat and R. Iranpour
Department of neonatology, Emamreza hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract.Objective: Clofibrate is a glucuronosyl transferase inducer that has been proposed to increase the elimination of bilirubin in neonates with hyperbilirubinemia. The aim of this study was to characterize the therapeutic effect of clofibrate in neonates born at full term and present with non-hemolytic jaundice. Methods: A clinical controlled study was performed in two groups of healthy full term neonates. Thirty neonates were treated with a single oral dose of clofibrate (100 mg/kg) plus phototherapy (clofibrate-treated group) while another 30 neonates (control group) received only phototherapy.Result: The mean plasma total bilirubin levels of 12th, 24 th and 48th hours were significantly lower in the clofibrate-treated group as compared with the control group (P < 0.0001, P < 0.0001 and P = 0.004, respectively). Treatment with clofibrate also resulted in a shorter duration of jaundice and a decreased use of phototherapy (P < 0.0001 ). No side effects were observed.
Conclusion: Although other pharmacological agents such as metalloporphyrins and Sn-mesoporphyrin also seem to be effective in decreasing bilirubin production, these products are not available for routine use and cannot be used because the safety of these drugs has to be confirmed prior to their widespread use. Therefore, clofibrate is now the only available pharmacological treatment of neonatal jaundice.
Ref:{Indian J Pediatr. 2005; 72(2): 123-126}
Keywords: Clofibrate; Hyperbilirubinemia; Jaundice; Neonate
 
 
 
Effect of Cotoneaster tricolor Pojark Manna on Serum Bilirubin Levels in Neonates
 
 
Ahmad Shah Farhat, Ashraf Mohammadzadeh, Mehvar Amiri and Mohammad Ramezani
Mashhad University of Medical Sciences, Mashhad, Iran
Pharmaceutica and Biotechnology Research Centers,
Bu-Ali Research Institute and School of Pharmcy,
Mashhad University of Medical Sciences, P.O. Box 91775-1365, Mshhad, Iran
Abstract: The effect of Cotoneaster discolor pojark manna known as Shirkhesht in Iran (a remedy used in traditional medicine for the treatment of neonatal jaundice) in a double blind placebo controlled trial in subjects with neonatal jaundice was evaluated. One hundred and four neonates (50 and 54 in case and control groups, respectively) with jaundice who had bilirubin level of 18-29 mg dL-1 were included in the trial. Newborns with weight less than 2.5 kg, renal failure, systemic infectious diseases, prior use of Cotoneaster manna, high bilirubin level who required transfusion were not included in the study. Patients received either a single dose of manna (6 g) or placebo (starch in distilled water, 0.1%) in the first hour of trial in addition to phototherapy. The bilirubin level was determined in blood samples every 12 h until bilirubin level reduced to less than 15 mg dL-1 and 24 h after phototherapy discontinued. Phototherapy was discontinued when bilirubin levels fell below 15 mg dL-1. The results indicated that the bilirubin level drops from 23 mg dL-1 on the first day of trial to 14 mg dL-1 on third day of trial in both case and control groups in a similar manner. Therefore, it could be suggested that the administration of Cotoneaster manna did not have any effect on bilirubin level providing no basis for use of the drug in neonate jaundice.
Keywords: neonatal jaundice, Cotoneaster discolor manna, biliribin level
Ref: International journal of pharmacology 2(4):455-458,2006
 
 
 
 • • • •  آيا انجام ختنه(circumcision) خطر ايكتر نوزادي را افزايش مي دهد؟
 
 
 
هدف اين مطالعه، اثر انجام ختنه در روزهاي اول زندگي و اثر احتمالي آن بر دفعات شير خوردن و احتمال اثر بر مقدار بيلي روبين سرم بود.
روش: 60 نوزاد پسر كه 30 تا از آن ها ختنه شده بودند مورد بررسي قرار گرفتند، اين كودكان داراي سن حاملگي 35 تا 40 هفته بودند. وزن بيش از 3 كيلو گرم داشتند و هيچ مشكل پري ناتال يا پس از تولد نداشتند.
تغييرات وزن، فركانس تغذيه، ادرار، دفع مدفوع و سطح بيلي روبين سرم مقايسه شد.
نتايج: در مراكز مناسب، ختنه نوزاد در روز دوم تولد روي دفعات تغذيه نوزاد، يا دفعات دفع مدفوع در روز سوم اثري نداشت و همچنين باعث افزايش بيلي روبين در روز چهارم تولد نشد. بنابراين باعث افزايش خطر ايكتر نوزاد نمي شود.
Ref: Acta paediater.208 sep; 97(9):1192-3
ترجمه: دكتر آناهيتا عليزاده قمصري
 
 
صفحه: 1 > 2> 3> 4

دانشگاه علوم پزشکی مشهد | Mashhad University of Medical Sciences | جامعة مشهد للعلوم الطبية
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